Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury
نویسندگان
چکیده
Our findings demonstrate the pivotal importance of caspase-3 in regulating renal microvascular dysfunction, fibrogenesis, and long-term impairment after acute kidney injury induced by ischemia-reperfusion injury. Furthermore, this study establishes predominant role peritubular capillary integrity as a major contributor to progressive dysfunction
منابع مشابه
Peritubular capillary preservation with COMP-angiopoietin-1 decreases ischemia-reperfusion-induced acute kidney injury.
Ischemia followed by reperfusion induces microvascular endothelial cell injury, leading to the loss of functions such as regulation of vascular tone, tissue perfusion, permeability, and inflammation in kidney. Improvement of this endothelial dysfunction could be a good approach to treating ischemia-reperfusion-induced renal injury. Cartilage oligomeric matrix protein-angiopoietin-1 (COMP-Ang1) ...
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ژورنال
عنوان ژورنال: American Journal of Physiology-renal Physiology
سال: 2021
ISSN: ['1522-1466', '1931-857X']
DOI: https://doi.org/10.1152/ajprenal.00690.2020